Isotropic-nematic phase transition in amyloid fibrilization.
نویسنده
چکیده
We carry out a theoretical study on the isotropic-nematic phase transition and phase separation in amyloid fibril solutions. Borrowing the thermodynamic model employed in the study of cylindrical micelles, we investigate the variations in the fibril length distribution and phase behavior with respect to changes in the protein concentration, fibril's rigidity, and binding energy. We then relate our theoretical findings to the nematic ordering experimentally observed in Hen Lysozyme fibril solution.
منابع مشابه
Investigation into the temperature dependence of isotropic- nematic phase transition of Gay- Berne liquid crystals
Density functional approach was used to study the isotropic- nematic (I-N) transition and calculate the values of freezing parameters of the Gay- Berne liquid crystal model. New direct and pair correlation functions of a molecular fluid with Gay- Berne pair potential were used. These new functions were used in density functional theory as input to calculate the isotropic- nematic transition den...
متن کاملGelation, phase behavior, and dynamics of β-lactoglobulin amyloid fibrils at varying concentrations and ionic strengths.
We have investigated the thermodynamic and dynamic behavior of multistranded β-lactoglobulin protein fibrils in water, by combining static, dynamic, and depolarized dynamic light scattering (SLS, DLS, DDLS), small angle neutron scattering (SANS), rheology, and cryogenic transmission electron microscopy (cryo-TEM). We focus on the region of the phase diagram at which ionic strength and concentra...
متن کاملLiquid crystalline phase behavior of protein fibers in water: experiments versus theory.
We have developed a new method allowing the study of the thermodynamic phase behavior of mesoscopic colloidal systems consisting of amyloid protein fibers in water, obtained by heat denaturation and aggregation of beta-lactoglobulin, a dairy protein. The fibers have a cross section of about 5.2 nm and two groups of polydisperse contour lengths: (i) long fibers of 1-20 microm, showing semiflexib...
متن کاملHelix inversion in the chiral nematic and isotropic phases of a liquid crystal
Measurements of the chirality (2 pi/pitch) in the chiral nematic phase and of a structural constant proportional to the chirality in the isotropic liquid for a system in which a helix inversion line crosses the chiral nematic to isotropic phase transition line are reported. While the chirality shows a strong temperature dependence in the chiral nematic phase, it loses all temperature dependence...
متن کاملCapillary and anchoring effects in thin hybrid nematic films and connection with bulk behavior.
By means of a molecular model, we examine hybrid nematic films with antagonistic anchoring angles where one of the surfaces is in the strong anchoring regime. If anchoring at the other surface is weak, and in the absence of wetting by the isotropic phase, the anchoring transition may interact with the capillary isotropic-nematic transition. For general anchoring conditions on this surface we co...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Physical review. E, Statistical, nonlinear, and soft matter physics
دوره 80 3 Pt 1 شماره
صفحات -
تاریخ انتشار 2009